PGD (Pre-implantation genetic Diagnosis) different genetic test, utilized by the doctors to research whether or not the In Vitro fertile embryo is appropriate for implantation within the female internal reproductive organ and can lead to a made maternity or not.
Embryos with abnormal chromosomes or genes usually lead to either miscarriages, a unsuccessful treatment cycle or a baby with a body or a inherited disease.
PGD is performed to notice cistrontic defects or single gene mutations among the embryos, thence preventing bound genetic diseases to be passed on to the baby.
Whereas PGS is performed to notice whether or not the embryo consists of any body abnormalities and if it's a traditional range of chromosomes or not.
PGD is a technique performed before implantation of associate in vitro fertile embryo. it's performed on the embryo to notice any desoxyribonucleic acid amendment or mutation of a specific sequence, referred to as one sequence disorder or a Mendelian disorder. These disorders notably pass from the oldsters to offspring and thus area unit necessary to be detected before implantation into the mother’s womb is performed. The prevalence of single genetic mutation is rare, but if each the oldsters area unit carriers of that specific alteration then the possibilities of their offspring inheritable the disease are high. Therefore, PGD permits the oldsters to decide on disease free and healthy embryos.
PGD Steps to Start Procedure
- After the IVF method of egg retrieval and fertilization in an exceedingly laboratory takes place, the embryo starts to divide into multiple cells.
- Around day five of cell multiplication, many cells from the embryo square measure removed small surgically for examination and also the embryos square measure frozen.
- Then polymer analysis is performed on the cells of every embryo to visualize for inheritance of a selected chromosomal mutation.
- When the PGD technique labels the embryos mutation-free, the embryo(s) square measure transferred within the female internal reproductive organ and couples square measure asked to attend for implantation and a positive gestation result.
- If there are more than embryos that square measure mutation-free, they're frozen safely to be used later for implantation, whereas embryos with mutation(s) square measure destroyed.
When PGD is Suitable:
- Carriers of single point mutation disorders
- Carriers of sex coupled genetic disorders
- Parent(s) with body disorders
- Women aged thirty five years and higher than
- Women with over one unsuccessful try of fertility treatment
- Women with repeated physiological state loss
PGD detects following diseases
- Cystic fibrosis
- Sickle cell anemia
- Myotonic dystrophy
- Fragile X syndrome